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KMID : 0606920080160040403
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Biomolecules & Therapeutics
2008 Volume.16 No. 4 p.403 ~ p.409
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Suppressive Effect of a Carbohydrate Fraction from Eclipta prostrata on the Apoptosis of the Mouse Splenocytes in Culture
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Bae Eun-Kyong
Lee Kang-Ro
Youn Hyun-Joo
Kim Na-Ri
Yun Mi-Jung
Youn Hyong-Chol
Youn Kyung-Joon
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Abstract
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Eclipta prostrata grows abundantly in the tropical and the sub-tropical parts of the world including most part of the Korean Peninsula. The plant has been traditionally used for the treatment of a number of inflammatory diseases including hepatitis and enteritis but the nature of its immuno-modulating activity needs more studies. In this study, water-soluble sugar-containing fractions were purified from the herb and their effects on the culture of mouse splenocytes were examined. One of the fractions significantly suppressed apoptosis of the splenocytes in culture, which involves the gene expression regulation of a number of cytokines and cytokine receptors including MIP1-. This study could explain an immunological activity of Eclipta prostrata and would lead to identify an immuno-active compound from the plant.
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KEYWORD
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Apoptosis, Eclipta, Splenocytes, Carbohydrates, MIP1-
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